Effectiveness of drug tests in outpatients starting opioid substitution therapy

Publié le 12 mars 2013

Dupouy et al., Journal of Substance Abuse Treatment, 2013

  • Titre traduit : Efficacité des tests de recherche de toxiques sur le maintien sous traitement de patients débutant un médicament substitutif aux opiacés en médecine ambulatoire
  • Auteurs : J. Dupouy, L. Dassieu, R. Bourrel, JC. Poutrain, S. Bismuth, S. Oustric, M. Lapeyre-Mestre
  • Résumé : We aimed to assess the effectiveness of drug tests for treatment retention in outpatients starting opioid substitution therapy. A retrospective cohort was created from the data of the French health insurance system database for the Midi-Pyrenees region. Patients starting opioid substitution treatment (OST) were included and followed for 18 to 30 months. Two groups of patients were defined: the drug test group (at least one drug test reimbursement) and a control group (no drug test reimbursement). The cohort included 1,507 patients. During follow-up, 39 subjects (2.6%) had at least one drug test reimbursement. Mean treatment retention was 207 days in the control group and 411 days in the drug test group (P < 0.001). With a multivariate Cox model, drug tests were associated with treatment retention: hazard ratio 0.55 [95% CI: 0.38 – 0.80]. Use of a drug test in follow-up of opioid substitution treatment, although rarely prescribed, significantly improved treatment retention.
  • Référence : J Subst Abuse Treat. 2013 Jan 19. pii: S0740-5472(12)00439-4.
  • Liens :
    • Résumé sur PubMed
    • Texte intégral sur addictovigilance.fr + (accès restreint aux seuls Centres d’Addictovigilance)
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