Lapeyre-Mestre et al., Drug and Alcohol Dependence, 2003
- Titre traduit : Substitution aux opiacés en soins ambulatoires : une étude de suivi de 24 semaines pour les nouveaux usagers
- Auteurs : M. Lapeyre-Mestre, M.-E. Llau, M. Gony, A.-M. Navel, J. Bez, M. Grau, J.-L. Montastruc
- Revue : Drug and Alcohol Dependence
- Résumé :
- Background: Many studies suggest that buprenorphine, a long acting partial opioid agonist, may be comparable to methadone in efﬁcacy, with fewer withdrawal symptoms and a lower risk of overdose. The aim of this study was to assess the patterns of buprenorphine prescription use in ambulatory care and retention rate under treatment during a 24-week follow-up period.
- Methods: This observational cohort study included buprenorphine users identiﬁed from the French Health System prescription database in an area of 1 million inhabitants and followed for 24 weeks.
- Results: We selected 282 users of buprenorphine deﬁned as “new users” (74% male, mean age 32.4 ± 6.2 years). Three groups were deﬁned: 50% of “rational users” (141 subjects, no more than 2 prescribers), 24% of “occasional users” (67 subjects, less than 2 buprenorphine prescriptions) and 26% of “non-rational users” (74 subjects, 3 or more prescribers). The overall 24-week treatment retention rate was 37%. Misuse of buprenorphine or benzodiazepines was signiﬁcantly more frequent in “non-rational” than “rational users”.
- Conclusion: The retention rate with buprenorphine estimated in this observational study was very similar to that obtained in controlled trials. A majority of regular users of buprenorphine could be regarded as “rational users” in this area of France.
- Référence : Drug and Alcohol Dependence 72 (2003) 297–303